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Updated: Jul 7, 2026
06:32
Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
Published on: October 24, 2016
Summary
A dog developed peptic esophagitis and duodenal ulcers due to a malignant pancreatic islet cell tumor. This rare gastrinoma in a non-human species may offer a new animal model for studying Zollinger-Ellison syndrome.
Area of Science:
- Veterinary Medicine
- Oncology
- Gastroenterology
Background:
- Peptic esophagitis and duodenal ulceration are uncommon in dogs.
- Malignant pancreatic islet cell tumors can produce hormones like gastrin and ACTH.
- The Zollinger-Ellison syndrome is characterized by excessive gastrin production leading to ulcers.
Purpose of the Study:
- To report an unusual case of peptic esophagitis and duodenal ulceration in a dog.
- To investigate the association between these gastrointestinal lesions and a pancreatic tumor.
- To explore the potential of this case as an animal model for Zollinger-Ellison syndrome.
Main Methods:
- Clinical case reporting.
- Diagnostic imaging (ultrasound, CT).
- Histopathological examination of the pancreatic tumor.
- Hormone level analysis (gastrin, ACTH).
Main Results:
- A malignant pancreatic islet cell tumor was identified.
- The tumor was confirmed to produce both gastrin and ACTH.
- The dog presented with severe peptic esophagitis and duodenal ulceration.
- This represents the first documented case of a gastrinoma in a dog.
Conclusions:
- Malignant pancreatic islet cell tumors producing gastrin and ACTH can cause severe gastrointestinal ulceration in dogs.
- This case highlights the potential for a canine model to study the multifaceted aspects of Zollinger-Ellison syndrome.
- Further research into this animal model could advance understanding of gastrinoma and its metabolic effects.
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