Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enzyme isoforms may increase phenotypic robustness.

Maurizio Tomaiuolo1, Richard Bertram, David Houle

  • 1Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA. mtomaiuolo@bio.fsu.edu

Evolution; International Journal of Organic Evolution
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb.

The Journal of physiology·2026
Same author

Behavior evolves as a correlated response to selection on cuticle color in Drosophila melanogaster and D. simulans.

Evolution; international journal of organic evolution·2026
Same author

Erg currents support electrical bursting in murine anterior pituitary corticotrophs.

The Journal of physiology·2026
Same author

Resource stewardship learning needs in undergraduate medical training: a cross-sectional study.

MedEdPublish (2016)·2026
Same author

High Burden of Constipation Among Autistic Youth: A Nationwide Query Powered by PCORnet.

The American journal of gastroenterology·2026
Same author

Volume electron microscopy reveals heterogeneity of the hemostatic response in veins and arteries.

Blood advances·2026
Same journal

The role of microbial resource mutualists in plant adaptation to abiotic environments.

Evolution; international journal of organic evolution·2026
Same journal

Museum genomics links MC1R alleles to adaptive winter coat color polymorphism in the long-tailed weasel.

Evolution; international journal of organic evolution·2026
Same journal

Repeated evolution of iridescence and hindwing tails is associated with morphometric flight proxies in skipper butterflies.

Evolution; international journal of organic evolution·2026
Same journal

Temperature-dependent competition predicts contrasting outcomes of adjacent secondary contact zones in darters (Percidae:Etheostoma).

Evolution; international journal of organic evolution·2026
Same journal

Sex allocation of hermaphrodites in metapopulations with frequent population extinction and recolonization.

Evolution; international journal of organic evolution·2026
Same journal

The phylogenetic signal of extinction through the rise and fall of early vertebrates: field of bullets or clustered strike?

Evolution; international journal of organic evolution·2026
See all related articles

Enzyme isoforms can enhance system robustness by increasing phenotypic stability. Controlling isoform proportions dynamically can buffer against variations in cellular reaction parameters.

Area of Science:

  • Biochemistry
  • Evolutionary Biology
  • Systems Biology

Background:

  • Enzyme isoforms, variants catalyzing similar reactions, play roles in cellular processes but their evolutionary significance is not fully understood.
  • Phenotypic robustness, the ability of a system to maintain function despite perturbations, is crucial for organismal survival.

Purpose of the Study:

  • To investigate the hypothesis that enzyme isoforms are evolutionarily favored for their role in enhancing phenotypic robustness.
  • To explore how differing substrate affinities of isoforms can contribute to system stability.

Main Methods:

  • Mathematical modeling of circadian clock gene expression in Drosophila.
  • Incorporation of enzyme isoforms with varying substrate affinities into the phosphorylation pathway of the period gene.

Related Experiment Videos

Main Results:

  • Dynamic control over the relative expression of isoforms increases system stability.
  • Controlling isoform proportions effectively reduces the impact of parameter variations, thereby enhancing robustness.

Conclusions:

  • Enzyme isoforms can be a mechanism for increasing phenotypic robustness in biological systems.
  • The regulation of isoform expression proportions is a key factor in achieving system stability and resilience.