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Updated: Jul 2, 2026
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
New therapeutic developments in renal cell cancer
Hans Prenen1, Thierry Gil, Ahmad Awada
1Department of General Medical Oncology, University Hospital Gasthuisberg, Catholic University Leuven, Herestraat 49, 3000 Leuven, Belgium. hans.prenen@uz.kuleuven.be
Critical Reviews in Oncology/Hematology
|August 30, 2008
Summary
Metastatic renal cell cancer is challenging to treat. New targeted therapies, including anti-angiogenic drugs and mTOR inhibitors, are revolutionizing treatment for this resistant cancer.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Metastatic renal cell cancer (mRCC) presents a poor prognosis and resistance to traditional chemotherapy.
- Advances in understanding mRCC molecular pathways have paved the way for novel therapeutic approaches.
Purpose of the Study:
- To review current treatment strategies for metastatic renal cell cancer.
- To highlight emerging targeted therapies, including anti-angiogenic agents and mTOR inhibitors.
Main Methods:
- Literature review of current and emerging treatments for mRCC.
- Focus on targeted therapies based on molecular pathogenesis.
Main Results:
- Several targeted therapies, including sunitinib, sorafenib, temsirolimus, and bevacizumab (with IFN-alpha), have been approved.
- These agents represent a significant shift in mRCC management.
Conclusions:
- Targeted therapies, particularly anti-angiogenic drugs and mTOR inhibitors, offer new hope for patients with metastatic renal cell cancer.
- The landscape of mRCC treatment has been significantly altered by these advancements.
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