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Whole-cell Currents Induced by Puff Application of GABA in Brain Slices

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Published on: October 12, 2017

GABAergic circuits control input-spike coupling in the piriform cortex.

Victor M Luna¹, Nathan E Schoppa

¹Department of Physiology and Biophysics, University of Colorado at Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|August 30, 2008

Summary

This summary is machine-generated.

Mammalian odor processing relies on synchronized gamma frequency oscillations. This study reveals how piriform cortex pyramidal cells precisely interpret these synchronized inputs through feedforward inhibition, ensuring faithful odor signal transmission.

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Area of Science:

Neuroscience
Olfactory System Research
Mammalian Sensory Processing

Background:

Mammalian odor coding is thought to involve synchronized gamma frequency (30-70 Hz) oscillations originating in the olfactory bulb.
The mechanisms by which downstream cortical structures, like the piriform cortex, interpret these olfactory bulb inputs remain largely unknown.

Purpose of the Study:

To investigate the cellular mechanisms in the rat piriform cortex responsible for integrating inputs from olfactory bulb mitral cells.
To understand how synchronized gamma frequency oscillations are processed and represented in the piriform cortex.

Main Methods:

Patch-clamp recordings were performed in rat piriform cortex slices.
Electrical stimulation of mitral cell axons in the lateral olfactory tract (LOT) was used to evoke responses in pyramidal cells (PCs).

Main Results:

Stimulation of LOT evoked excitation in PCs, followed by a reproducible, somatic inhibition approximately 10 ms later.
This inhibition, driven by feedforward activation of GABAergic interneurons, precisely timed action potential firing in PCs.
PCs were limited to firing one action potential per excitatory input and preferentially responded to synchronized inputs within a <5 ms window.

Conclusions:

Feedforward inhibition in the piriform cortex plays a crucial role in shaping pyramidal cell responses to olfactory bulb inputs.
These inhibitory mechanisms ensure that pyramidal cells accurately and selectively respond to synchronized gamma frequency patterns, crucial for olfactory coding.