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Related Experiment Video

Updated: Jul 2, 2026

Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol
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Rethinking a right hemisphere deficit in ADHD.

T Sigi Hale1, Sandra K Loo, Eran Zaidel

  • 1UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA. sig@ucla.edu

Journal of Attention Disorders
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

Right hemisphere (RH) processing with interhemispheric interaction is crucial in ADHD, not isolated RH function. This finding supports RH involvement in cognitive tasks, impacting ADHD.

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Child Psychiatry

Background:

  • Previous research suggested right hemisphere (RH) dysfunction in Attention-Deficit/Hyperactivity Disorder (ADHD).
  • Alternative theories propose increased RH > LH asymmetry and abnormal interhemispheric interaction in ADHD.
  • This study investigated whether RH pathology in ADHD involves networked and overactivated functioning.

Purpose of the Study:

  • To evaluate the role of interhemispherically networked right hemisphere (RH) processing in ADHD.
  • To examine the association of lateralized brain function with cognitive ability, psychiatric comorbidity, and sibling correlations in children with ADHD.

Main Methods:

  • Measured four elements of lateralized brain function: LH specialized, RH specialized, LH with interhemispheric processing (LH/IH), and RH with interhemispheric processing (RH/IH).
  • Assessed associations with cognitive ability, psychiatric comorbidity, and sibling correlations.
  • Studied 79 children diagnosed with ADHD.

Main Results:

  • Right hemisphere processing with interhemispheric interaction (RH/IH) was uniquely associated with outcome measures.
  • No significant associations were found for independent left hemisphere (LH) or RH function alone.
  • Lack of association between LH specialized processing and cognitive ability supports increased RH mediation.

Conclusions:

  • Interhemispherically networked RH processing is critical in the neurobiology of ADHD.
  • The findings suggest RH mediation of cognitive tasks, particularly verbal tasks, in ADHD.
  • This research highlights the importance of considering interhemispheric interactions in ADHD pathophysiology.