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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 8. Side chain ether analogues of lovastatin
T J Lee1, W J Holtz, R L Smith
1Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486.
Journal of Medicinal Chemistry
|August 1, 1991
Abstract:
A general route for preparing side chain ether analogues of lovastatin is presented. These analogues proved to be weaker inhibitors of HMG-CoA reductase than the corresponding side chain ester analogues. Interestingly, inhibitory potency was enhanced markedly when the 4-fluoro group was incorporated in the aromatic moiety of the side chain benzyl group of 2d.