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Cyclic AMP, glucose and cortisol in plasma during surgery.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|November 1, 1976
Summary
Plasma levels of cyclic AMP (adenosine monophosphate), glucose, and cortisol increase with surgical trauma severity. Major surgeries showed significantly higher elevations compared to minor procedures, indicating a stress response correlation.
Area of Science:
- Endocrinology
- Surgical Physiology
- Metabolic Research
Background:
- Surgical procedures induce physiological stress.
- Hormonal and metabolic responses to stress are critical areas of study.
Purpose of the Study:
- To investigate the relationship between surgical trauma severity and plasma levels of cyclic AMP, glucose, and cortisol.
- To compare these biochemical markers during major versus minor surgical interventions.
Main Methods:
- Plasma samples were collected from patients undergoing major (hysterectomy) and minor (tympanoplasty) surgery.
- Measurements of cyclic AMP, glucose, and cortisol were performed pre-operatively, intra-operatively, and post-operatively.
Main Results:
- Major surgery led to a pronounced increase in plasma cyclic AMP, glucose, and cortisol.
- Minor surgery resulted in significantly lower elevations of these parameters compared to major surgery.
Conclusions:
- The observed increase in plasma cyclic AMP during surgery is directly related to the severity of the surgical trauma.
- These findings suggest cyclic AMP as a potential indicator of surgical stress response.