Fatal very late stent thrombosis in a young diabetic patient with severely diffuse coronary atherosclerosis

Tadayuki Kadohira1, Yoshio Kobayashi, Tatsuhiko Asano

  • 1Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.

Insights

Fatal stent thrombosis occurred in a young diabetic patient due to poor adherence to treatment. This highlights the risks of drug-eluting stents (DES) and the critical need for patient education on dual antiplatelet therapy.

Area of Science:

  • Cardiology
  • Endocrinology
  • Medical Case Reports

Background:

  • Stent thrombosis is a rare but serious complication of coronary stenting.
  • Long-term antiplatelet therapy is crucial for preventing late stent thrombosis after drug-eluting stent (DES) implantation.
  • Diabetic patients with poor glycemic control often exhibit diffuse coronary atherosclerosis and microvascular complications.

Observation:

  • This case report details a fatal instance of very late stent thrombosis in a young patient with diabetes.
  • The patient demonstrated nonadherence to prescribed diabetic treatments.
  • The patient had severely diffuse coronary atherosclerosis.

Findings:

  • Nonadherence to diabetic treatment contributed to advanced atherosclerosis.
  • Drug-eluting stents (DES) may pose risks in diabetic patients with acute myocardial infarction.
  • Very late stent thrombosis can be fatal, even in young patients.

Implications:

  • Emphasizes the critical importance of patient education regarding long-term dual antiplatelet therapy adherence after DES implantation.
  • Highlights the increased risk of cardiovascular complications in diabetic patients with poor glycemic control.
  • Underscores the need for vigilant monitoring and management of diabetes in patients undergoing coronary stenting.

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...