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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

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Related Experiment Video

Updated: Jul 2, 2026

Mouse Genome Engineering Using Designer Nucleases
12:04

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

The mouse genome.

S D M Brown1, J M Hancock

  • 1MRC Mammalian Genetics Unit, Harwell, UK.

Genome Dynamics
|August 30, 2008
PubMed
Summary

The mouse genome sequence is crucial for understanding mammalian genetics and evolution. Future research will systematically mutate mouse genes to identify human disease models.

Area of Science:

  • Mammalian Genetics
  • Genomics
  • Comparative Genomics

Background:

  • The mouse serves as a vital model organism in biological research.
  • Determining the mouse genome sequence was a priority for the genome project.
  • A draft sequence was released in 2002, with ongoing chromosome completion.

Purpose of the Study:

  • To leverage the annotated mouse genome for comprehensive functional analysis.
  • To facilitate the generation of mutations across the entire mouse genome.
  • To identify and characterize mouse models for human genetic diseases.

Main Methods:

  • Comparative analysis of the mouse genome with human and other mammalian genomes.
  • Genome sequencing and annotation efforts.
  • Systematic mutagenesis strategies.

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Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
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Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

Generation of Mice Derived from Induced Pluripotent Stem Cells
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Generation of Mice Derived from Induced Pluripotent Stem Cells

Published on: November 29, 2012

Related Experiment Videos

Last Updated: Jul 2, 2026

Mouse Genome Engineering Using Designer Nucleases
12:04

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
11:13

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

Generation of Mice Derived from Induced Pluripotent Stem Cells
11:56

Generation of Mice Derived from Induced Pluripotent Stem Cells

Published on: November 29, 2012

Main Results:

  • Comparative genomics provided insights into mammalian genome evolution.
  • Assisted in the annotation of both mouse and human genomes.
  • A well-annotated mouse genome sequence is now available.

Conclusions:

  • The annotated mouse genome enables systematic gene mutation generation.
  • This approach is key for comprehensive functional genome annotation.
  • It will accelerate the identification of models for human genetic disorders.