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Related Concept Videos

X-Inactivation01:58

X-Inactivation

The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

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Related Experiment Video

Updated: Jul 2, 2026

Chromatin Immunoprecipitation of Murine Brown Adipose Tissue
07:50

Chromatin Immunoprecipitation of Murine Brown Adipose Tissue

Published on: November 21, 2018

The feline genome.

W J Murphy1

  • 1Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Tex., USA.

Genome Dynamics
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

Domestic cats serve as valuable models for human genetic diseases, with nearly half of feline genetic disorders having human counterparts. Advances in feline genomics and mapping resources now enable precise gene identification for both feline and human health.

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Area of Science:

  • Genomics
  • Comparative Biology
  • Veterinary Medicine

Background:

  • The domestic cat has historically contributed to understanding human biology.
  • Many feline genetic diseases share homologous counterparts in humans, presenting research opportunities.
  • Studying these feline diseases offers insights into human hereditary and infectious diseases.

Purpose of the Study:

  • To review advancements in feline genomic mapping resources and genome sequencing.
  • To highlight the utility of the domestic cat as a model organism for human disease research.
  • To discuss the role of feline genomics in enhancing feline health and comparative genomics.

Main Methods:

  • Review of progress in feline genomic mapping resource development.
  • Analysis of the impact of a 2x feline genome sequence acquisition.
  • Discussion of genetic characterization of feline genetic disease models.

Main Results:

  • Genomic mapping resources and a feline genome sequence are now available.
  • These tools empower feline geneticists to identify and characterize disease-related genes.
  • The cat gene map aids in multispecies comparative genomic analyses.

Conclusions:

  • The domestic cat is an increasingly valuable model for human disease research.
  • Enhanced genomic tools will accelerate the identification of genes causing comparable diseases in cats and humans.
  • These advancements will benefit both human health and feline species welfare.