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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

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Cognitive dysfunction in an urban Indian population--some observations.

T K Banerjee¹, C S Mukherjee, A Dutt

¹National Neurosciences Centre Calcutta, Kolkata, India. tapaskumarb@gmail.com

Neuroepidemiology

|August 30, 2008

Summary

This study investigated dementia prevalence in India, finding low rates. Mild cognitive impairment (MCI) outcomes in Indian elderly were similar to Western populations, with static, progressive, or normal transitions observed.

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Area of Science:

Neurology
Epidemiology
Geriatrics

Background:

Limited prospective studies on mild cognitive impairment (MCI) exist for India.
Understanding dementia prevalence and MCI progression is crucial for public health in aging populations.

Purpose of the Study:

To determine the prevalence of dementia in Kolkata, India.
To prospectively analyze the outcomes of individuals with MCI.
To compare MCI progression in India with Western cohorts.

Main Methods:

A door-to-door cross-sectional cluster survey of over 50,000 individuals aged >50 years in Kolkata.
Annual cognitive assessments over 4 years for 21 elderly individuals with memory complaints.
Validated questionnaire battery used for cognitive function evaluation.

Main Results:

Crude dementia prevalence rates were 0.62% (>50 years) and 1.25% (>60 years). Weighted prevalence was 0.95% (>50 years).
Alzheimer's disease (55%) and vascular dementia (36%) were the most common subtypes.
MCI outcomes included static conditions, conversion to dementia, reversion to normalcy, or subtype transitions, mirroring Western findings.

Conclusions:

Dementia prevalence in Eastern India is notably low compared to global estimates.
MCI exhibits diverse, dynamic trajectories in the elderly Indian population.
Findings provide essential data for understanding and managing cognitive decline in India.