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Updated: Jul 2, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
Endothelial markers in schistosomiasis patients with or without portal hypertension
Carlos Fischer de Toledo1, Claudia Teresa Carvente, David Carlos Shigueoka
1Department of Medicine, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil.
Purpose:
To evaluate the serum levels of von Willebrand factor (vWF), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), and endothelin-3 (ET-3) in patients with the isolated, inactive form of Schistosomiasis mansoni. Patients were classified into two groups: 10 patients without (SM group) and 18 with (PH group) portal hypertension.
Results:
Serum albumin, VEGF, and vWF levels did not differ between the two groups (P > 0.05). The prothrombin time (INR), number of platelets, spleen size, splenic vein diameter, and endothelin levels differentiated the PH group, which showed decreased ET-1 (SM = 22.4 +/- 2.4 pg/ml and PH = 16.4 +/- 1.5 pg/ml; P = 0.034) and increased ET-3 (SM = 2.1 +/- 0.1 ng/ml and PH = 3.2 +/- 0.1 ng/ml; P = 0.000) levels.
Conclusions:
In patients with schistosomiasis and portal hypertension (presinusoidal type), the levels of VEGF and ET-1 differ from those reported in patients with cirrhosis.
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