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Effect of preoperative intravenous pantoprazole in elective-surgery patients: a pilot study
Joseph R Pisegna1, Robyn G Karlstadt, Jeffrey A Norton
1CURE: Digestive Diseases Research Center, University of California, Los Angeles, CA, USA. jpisegna@ucla.edu
Background:
This study evaluated the effects of intravenous pantoprazole on gastric volume and acid output in elective-surgical patients.
Methods:
This is a multicenter, randomized, pilot study of adult patients receiving intravenous pantoprazole: 40 mg every 24 h, 40 mg every 12 h (q12h) or 80 mg q12h. The first dose was administered 1 h before general anesthesia for surgery. All gastric fluid was aspirated through a nasogastric tube 1 h before dosing and through the postoperative period. Aspirate volume was recorded; pH and H(+) concentrations were measured.
Result:
Twenty-six patients were enrolled and 21 were evaluable. Pantoprazole was well tolerated. All regimens decreased gastric acid output and volume, and increased pH within 1 h of dosing. Effects were sustained for up to 12 h following single-dose administration.
Conclusions:
Intravenous pantoprazole administered prior to anesthesia induction may be efficacious for the reduction of gastric volume and acid output, and for pulmonary aspiration prophylaxis in surgical patients.
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