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Fungal cytochrome P450 database.

Jongsun Park¹, Seungmin Lee, Jaeyoung Choi

¹Fungal Bioinformatics Laboratory, Seoul National University, Seoul 151-921, Korea. starflr@snu.ac.kr

|August 30, 2008

Summary

The Fungal Cytochrome P450 Database (FCPD) archives fungal P450 genes, enabling analysis of their roles and evolution. This bioinformatics platform supports systematic identification and multifaceted studies of these critical enzymes across diverse fungal species.

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Area of Science:

Mycology
Bioinformatics
Enzymology

Background:

Cytochrome P450 enzymes are crucial for fungal biology and ecology.
Rapidly accumulating fungal genome data necessitates specialized bioinformatics tools.
Understanding P450 roles and evolution in fungi is essential.

Purpose of the Study:

To develop an efficient bioinformatics platform for studying fungal cytochrome P450 enzymes.
To archive and facilitate analysis of P450 genes from diverse fungal species.

Main Methods:

Archived genes encoding P450s from 66 fungal and 4 oomycete species.
Classified P450s into 16 classes using InterPro terms.
Clustered P450s into 141 groups using tribe-MCL.

Main Results:

The Fungal Cytochrome P450 Database (FCPD) contains 4,538 P450 genes.
Analyses supported include sequence, chromosomal distribution, and evolutionary relationships.
P450 proportion and class distribution show taxon-specific patterns.

Conclusions:

The FCPD enables systematic identification and analysis of fungal P450s via the web.
Facilitates multifaceted P450 studies at multiple taxonomic levels.
Provides web access to all data and functions at http://p450.riceblast.snu.ac.kr/.