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[Brimonidine intoxication in paediatrics. A presentation as intracranial hypertension syndrome]

M A Fernández Fernández1, M D Morillo Rojas, M A Ribó Golovart

  • 1Servicio de Pediatría. Hospital Universitario Infantil Virgen del Rocío. Sevilla. España. Drlolo13@hotmail.com

Anales De Pediatria (Barcelona, Spain : 2003)
|August 30, 2008
PubMed

Insights

Brimonidine, a lipophilic drug, can cause severe central nervous system (CNS) effects, especially in children. Due to potential lethal adverse events, its use is prohibited in infants and toddlers.

Area of Science:

  • Ophthalmology
  • Neurology
  • Pharmacology

Background:

  • Brimonidine's high lipophilicity facilitates corneal absorption and blood-brain barrier penetration.
  • Understanding CNS penetration is crucial for assessing brimonidine's toxic potential.

Observation:

  • Adverse effects of brimonidine use were evaluated.
  • Particular attention was given to the pediatric population.

Findings:

  • Brimonidine is contraindicated in infants and toddlers due to severe and potentially lethal adverse effects.
  • Central nervous system (CNS) toxicity should be suspected in patients exhibiting compatible symptoms after brimonidine treatment, especially when organic disease is excluded.

Implications:

  • Discontinuation of brimonidine and implementation of supportive care are necessary upon suspected toxicity.
  • Clinical vigilance is required for pediatric patients using brimonidine.
  • This highlights the critical need for cautious prescribing and monitoring of brimonidine in vulnerable populations.
Abstract

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