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Predicting regional variations in trabecular bone mechanical properties within the human proximal tibia using MR

Sarah L Lancianese¹, Edmund Kwok, Christopher A Beck

¹Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627-0168, USA.

|August 30, 2008

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Magnetic resonance (MR) imaging can assess trabecular bone density in the proximal tibia, correlating with mechanical properties. This non-invasive technique aids in understanding bone strength and diagnosing knee joint disorders.

Area of Science:

Orthopedics
Radiology
Biomedical Engineering

Background:

Trabecular bone density changes in the proximal tibia are key indicators of musculoskeletal disorders like osteoarthritis and osteoporosis.
These disorders affect bone density, size, structure, and microarchitecture, increasing fracture risk.
Magnetic resonance (MR) imaging, typically for soft tissues, can non-invasively characterize 3D bone microstructure.

Purpose of the Study:

To utilize whole joint MR images for regional apparent bone volume fraction (appBVF) assessment in the proximal tibia.
To correlate MR-derived appBVF with ex vivo measured mechanical properties.
To compare MR imaging's bone characterization with micro-computed tomography (micro-CT).

Main Methods:

Whole joint MR imaging was used to acquire regional apparent bone volume fraction (appBVF).

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Mechanical properties (Young's modulus, yield stress, ultimate stress) were measured on ex vivo specimens.

Micro-CT analysis was performed on a subset of specimens for comparison.

Main Results:

Significant correlations were found between MR appBVF and mechanical properties (Young's modulus r(2)=0.58, yield stress r(2)=0.73, ultimate stress r(2)=0.72).
Micro-CT BVF also showed significant correlations with mechanical properties (Young's modulus r(2)=0.47, yield stress r(2)=0.80, ultimate stress r(2)=0.83).
MR imaging demonstrated its ability to detect regional bone strength variations.

Conclusions:

MR imaging is a viable in vivo tool for assessing bone strength in the proximal tibia.
This technique can differentiate bone strength between individuals and within a single tibia.
MR imaging offers a non-invasive method for characterizing bone microstructure relevant to knee joint disorders.