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Updated: Jul 2, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Potential liver damage associated with over-the-counter vitamin supplements
Ankur Sheth1, Ritu Khurana, Vikas Khurana
1Department of Gastroenterology, and R. Khurana is clinical fellow, Department of Rheumatology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Abstract:
The growing popularity and availability of over-the-counter (OTC) health products, including vitamins, raises serious concern about vitamin toxicity. We report a case of cirrhosis in a patient with habitual daily ingestion of an OTC dietary supplement that contained 13,000 microg vitamin A and was associated with marked clinical improvement after discontinuation. This case highlights the potential for liver damage that may be associated with long-term intake of OTC vitamin supplements, and indicates the need for medical supervision of such products.
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