[Blood biochemistry during acidosis associated with ATP-induced hypotensive anesthesia]

Several investigators reported metabolic acidosis during ATP-induced hypotensive anesthesia. To elucidate the etiology, we studied blood biochemistry during hypotensive anesthesia for tympanoplastic surgery. The blood concentration of lactic acid, uric acid, phosphoric acid and carbonic acid increased and their total amount coincided with the base excess change. We also found that metabolic intermediates of glycolysis and of the catabolic pathway of adenosine also increased proportionally. The result suggests that the metabolic change is caused by lactic acid produced from glycolysis promoted by ATP and by the catabolic products of administered ATP itself.