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Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis
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Association between Histoplasma exposure and stroke.

John D Cleary1, Margaret Pearson, Jake Oliver

  • 1School of Pharmacy, University of Mississippi Medical Center, Jackson, MS 39216, USA. jcleary@medicine.umsmed.edu

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

Adolescent exposure to Histoplasma capsulatum infection is linked to a higher risk of stroke later in life. This finding may help explain the increased stroke rates in the Southeastern United States stroke belt.

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Published on: August 18, 2015

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Neurology

Background:

  • The stroke belt region in the Southeastern US has higher cerebrovascular event rates than the rest of the nation.
  • Specific causes for this geographic disparity remain unclear despite research into various risk factors.
  • Historical data from 1958-1965 documented adolescent exposure to Histoplasma capsulatum.

Purpose of the Study:

  • To investigate the association between adolescent Histoplasma capsulatum exposure and the subsequent development of stroke.
  • To explore potential contributing factors to the elevated stroke rates within the stroke belt.

Main Methods:

  • A cross-sectional study analyzed medical records of 23,795 US Navy veterans.
  • Participants were part of a cooperative skin-testing program (1958-1965) that identified adolescent Histoplasma capsulatum exposure.
  • Logistic regression and propensity scores were used to control for confounding variables and estimate stroke risk.

Main Results:

  • Adolescent exposure to Histoplasma capsulatum was associated with a 1.34 adjusted odds ratio for stroke (95% CI: 1.1-1.6; P = .0033).
  • This increased stroke risk was independent of common cerebrovascular risk factors.
  • The model did not control for less frequent risk factors like atrial fibrillation or coronary heart disease.

Conclusions:

  • Exposure to Histoplasma capsulatum during adolescence is significantly associated with an increased risk of stroke.
  • This finding offers a potential explanation for the higher stroke prevalence in the US stroke belt.