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Hemorrhage from a falx meningioma after internal use of low-dose aspirin

Takahito Miyazawa1, Yoichi Uozumi, Terushige Toyooka

  • 1Department of Neurosurgery, National Defense Medical College, Tokorozawa, Japan. miyazawa-nsu@umin.net

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|August 30, 2008
PubMed

Insights

Low-dose aspirin use may increase the risk of bleeding in asymptomatic meningiomas, a type of brain tumor. Caution is advised when prescribing aspirin to patients with known meningiomas.

Area of Science:

  • Neurology
  • Oncology

Background:

  • Meningiomas are tumors that arise from the meninges, the membranes surrounding the brain and spinal cord.
  • Low-dose aspirin is commonly used for cardiovascular prophylaxis.

Observation:

  • A case of hemorrhage occurred in a previously asymptomatic falx meningioma after 16 months of low-dose aspirin use.
  • This is the second reported case suggesting a potential link between aspirin prophylaxis and meningioma hemorrhage.

Findings:

  • Aspirin may induce or promote hemorrhage within meningiomas.
  • Inadequate hypertension control could also contribute to meningioma hemorrhage.
  • The exact contribution of aspirin to intratumoral hemorrhage remains difficult to ascertain.

Implications:

  • Clinicians should exercise caution when prescribing aspirin to patients with asymptomatic meningiomas.
  • Further research is needed to elucidate the relationship between aspirin and meningioma bleeding risk.

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