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A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Design and synthesis of fluorescent SGLT2 inhibitors
Mark I Lansdell1, Denise J Burring, David Hepworth
1Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Kent CT139NJ, UK. mark.lansdell@pfizer.com
Bioorganic & Medicinal Chemistry Letters
|August 30, 2008
Abstract:
The design and synthesis of the first fluorophore-conjugated SGLT2 inhibitors is described. The mode of linking the fluorophore to the SGLT2 pharmacophore was found to be crucial in achieving optimum potency. Superior potency to phlorizin was provided by examples containing TAMRA, BODIPY, Cy3B and NBD fluorophores.

