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[A case of pleuritis tuberculosa which was diagnosed as inoculated tuberculosis after 43 years]

M Tamura1

  • 1Hyogo Chuo-Byoin National Sanatorium, Japan.

Kekkaku : [Tuberculosis]
|May 1, 1991
PubMed

Insights

In 1946, 102 children developed inoculated tuberculosis after receiving anti-typhoid vaccine. Of these, 26% later developed secondary tuberculosis, highlighting long-term risks.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Vaccinology

Background:

  • In 1946, a cohort of primary school children in Hyogo prefecture received anti-typhoid vaccinations.
  • A significant number of these children developed inoculated tuberculosis at the vaccination site.

Observation:

  • Over 25 years, 26% (26 out of 102) of children with inoculated tuberculosis progressed to secondary tuberculosis.
  • A 53-year-old woman, previously diagnosed with inoculated tuberculosis, was admitted in 1989 for pleuritis tuberculosa.
  • Her case was not previously categorized within the secondary tuberculosis group.

Findings:

  • The study identified a notable incidence of secondary tuberculosis following initial inoculation site tuberculosis.
  • The long-term sequelae of inoculated tuberculosis, even without progression to secondary disease, remain a concern, as exemplified by the pleurisy case.

Implications:

  • This suggests a potential for delayed or atypical presentations of tuberculosis years after initial inoculation.
  • Public health strategies may need to consider long-term monitoring for individuals with inoculation site tuberculosis.
  • Further research is warranted to elucidate the mechanisms and long-term outcomes of inoculated tuberculosis.

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