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[Effect of xanthinol niacinate on the autoimmunity and capillary permeability in patients with stable stenocardia]

E S Atroshchenko, I S Karpova, A B Cheshchevik

    Kardiologiia
    |March 1, 1991
    PubMed

    Insights

    Antianginal therapy using long-acting nitrates and xanthinol nicotinate improved clinical effects. This treatment reduced immune complexes, IgG, and capillary permeability, benefiting patients with angina.

    Area of Science:

    • Cardiology
    • Immunology
    • Pharmacology

    Background:

    • Angina pectoris is a common cardiovascular condition.
    • Current therapies aim to improve blood flow and reduce myocardial oxygen demand.
    • The role of immune complexes in angina pathophysiology requires further elucidation.

    Purpose of the Study:

    • To evaluate the clinical efficacy of a three-month antianginal therapy.
    • To investigate the effects of this therapy on immune complexes and IgG levels.
    • To assess the impact on capillary permeability and dienic conjugate levels.

    Main Methods:

    • A three-month therapeutic trial was conducted.
    • Patients received varying daily doses of long-acting nitrates and xanthinol nicotinate.
    • Clinical effects, immune complex levels, IgG, capillary permeability, and dienic conjugates were monitored.

    Main Results:

    • A positive clinical effect was observed in most patients.
    • Significant reduction in immune complexes and IgG levels was noted.
    • Decreased capillary permeability and dienic conjugate levels in erythrocytes and plasma were documented.

    Conclusions:

    • Combined therapy with long-acting nitrates and xanthinol nicotinate demonstrates therapeutic benefits in angina.
    • The treatment appears to modulate immune system components and vascular permeability.
    • Further research can explore the underlying mechanisms of these observed effects.

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