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Updated: Aug 14, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
[The role of genetic factors in determining the ECG indicators]
Abstract:
ECG parameters were examined in 62 families with a history of arterial hypertension. A genetical-and-dispersion analysis of ECG parameters were made. There was a high genetic determination with X-chromosomal effect, R-R interval duration, and Makruse index values. A high degree of inheritance of P-Q interval duration, left ventricular activation time and R wave height in the lead V6 was ascertained. The household more frequently displayed the early ventricular repolarization syndrome and the partial preexcitation syndrome. There was a genetic determination of these electrocardiographic phenomena. The findings provide evidence for the fact that search for genetic markers of arterial hypertension among ECG parameters seems to be promising.
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