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Related Concept Videos

Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Uterine Tubes01:16

Uterine Tubes

The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Uterus and Cervix01:18

Uterus and Cervix

The uterus, commonly called the womb, is a vital reproductive organ in females designed to provide a nurturing environment for the implantation and growth of an embryo. It is shaped like a hollow pear and positioned between the urinary bladder and the rectum. The uterus's structure allows it to support and protect a developing fetus throughout pregnancy.
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs of...
Histology of the Uterus01:19

Histology of the Uterus

The uterine wall consists of three histological layers: the perimetrium, myometrium, and endometrium. The outermost perimetrium is a thin, serous membrane connected with the broad ligament on the sides, which helps anchor the uterus in the pelvic cavity. The thickest layer, myometrium, is mainly made up of smooth muscle tissue bundles. Its contractions are vital in facilitating the expulsion of the uterine lining, fetus, and placenta during menstruation and childbirth.
The endometrium is the...

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Related Experiment Video

Updated: Jul 2, 2026

Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection
11:44

Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection

Published on: October 3, 2025

Intrauterine adhesions.

Jay M Berman1

  • 1Department of Obstetrics and Gynecology, Division of Gynecology, Wayne State University School of Medicine, Hutzel Women's Hospital, Detroit, Michigan 48201, USA. jberman@med.wayne.edu

Seminars in Reproductive Medicine
|August 30, 2008
PubMed
Summary

Asherman's syndrome, or intrauterine adhesions, often follows uterine procedures and can cause infertility. Diagnosis relies on imaging and hysteroscopy, with surgical lysis of adhesions offering treatment and potential for pregnancy.

Area of Science:

  • Reproductive Medicine
  • Gynecologic Surgery

Background:

  • Intrauterine adhesions, also known as Asherman's syndrome, are fibrous bands within the uterine cavity.
  • They are frequently linked to prior uterine procedures, particularly curettage after pregnancy.
  • The condition can manifest with varied menstrual disturbances and is often associated with infertility.

Purpose of the Study:

  • To review the current understanding of intrauterine adhesions, including their etiology, diagnosis, and treatment.
  • To discuss the diagnostic modalities and therapeutic interventions for Asherman's syndrome.
  • To highlight the challenges in assessing treatment outcomes and the need for further research.

Main Methods:

  • Diagnosis primarily involves clinical history and a high index of suspicion.

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Creation of Abdominal Adhesions in Mice
06:44

Creation of Abdominal Adhesions in Mice

Published on: August 27, 2016

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Last Updated: Jul 2, 2026

Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection
11:44

Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection

Published on: October 3, 2025

A Translational Surgical Porcine Model for Postoperative Intra-Abdominal Adhesion Formation
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A Translational Surgical Porcine Model for Postoperative Intra-Abdominal Adhesion Formation

Published on: March 13, 2026

Creation of Abdominal Adhesions in Mice
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Creation of Abdominal Adhesions in Mice

Published on: August 27, 2016

  • Confirmatory imaging includes saline infusion hysterography (SIS) or hysterosalpingogram (HSG).
  • Hysteroscopy is essential for definitive diagnosis and treatment via adhesiolysis.
  • Main Results:

    • Hysteroscopic lysis of adhesions is the primary treatment, sometimes requiring adjunct guidance.
    • Post-treatment pregnancy rates range from 22-45%, with live birth rates of 28-32%.
    • Pregnancy following treatment carries significant risks, including placenta accreta and hysterectomy.

    Conclusions:

    • Intrauterine adhesions are a significant cause of infertility and menstrual irregularities, often resulting from uterine trauma.
    • While hysteroscopic adhesiolysis improves pregnancy outcomes, challenges remain in standardizing classification and assessing success.
    • Further prospective studies are crucial for optimizing diagnostic and treatment strategies for Asherman's syndrome.