[Impact of obstructive jaundice upon hepatectomy: experiment with rats]

To investigate the impact of obstructive jaundice on hepatectomy.

120 Wistar rats underwent ligation of the common bile duct to establish animal model of obstructive jaundice. On days 1 after ligation 20 rats underwent 30% hepatic resection + choledochojejunostomy (Group 1) and 20 rats underwent 70% hepatic resection + choledochojejunostomy (Group 2); on day 3 after ligation 10 rats underwent 30% hepatic resection + choledochojejunostomy (Group 3) and 10 rats underwent 70% hepatic resection + choledochojejunostomy (Group 4); on day 5 20 rats underwent 30% hepatic resection + choledochojejunostomy (Group 5) and 20 rats underwent 70% hepatic resection + choledochojejunostomy (Group 6); and on day 7 10 rats underwent 30% hepatic resection + choledochojejunostomy (Group 7) and 10 rats underwent 70% hepatic resection + choledochojejunostomy (Group 8). The serum total protein, albumin, total bilirubin (TBIL), direct bilirubin, and alanine transaminase (ALT) were detected. Then livers were taken out after the rats died or were killed, and the levels of ALT and Na+ K+(-)ATPase were measure.

The serum TBIL peaked on day 3. The survival rate after the operation of Groups 1, 2, 3, 4, 5, 6, 7, and 8 were 20% , 20%, 100%, 50%, 30%, 20%, 0, and 0 respectively.

(1) It is the too short a time between two operations, but not liver dysfunction, that is responsible for the high death rate in Groups 1 and 2. (2) 30% hepatic resection + choledochojejunostomy performed 3 days after the ligation of common bile duct is safe with a survival rate of 100%. However, 70% hepatic resection + choledochojejunostomy is dangerous in this time with a survival rate of 50% only. (3) 30% and 70% hepatic resection + choledochojejunostomy performed 5 and 7 days after the ligation are very dangerous with a post-operational survival rate of zero.