Related Experiment Video
Updated: Jul 2, 2026

A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions
Published on: July 15, 2013
Chemokines as mediators of neovascularization
Ellen C Keeley1, Borna Mehrad, Robert M Strieter
1Department of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA 22908-0466, USA.
Abstract:
Chemokines are a superfamily of homologous heparin-binding proteins, first described for their role in recruiting leukocytes to sites of inflammation. Chemokines have since been recognized as key factors mediating both physiological and pathological neovascularization in such diverse clinical settings as malignancy, wound repair, chronic fibroproliferative disorders, myocardial ischemia, and atherosclerosis. Members of the CXC chemokine family, structurally defined as containing the ELR amino acid motif, are potent inducers of angiogenesis, whereas another subset of the CXC chemokines inhibits angiogenesis. In addition, CCL2, a CC chemokine ligand, has been implicated in arteriogenesis. In this article, we review the current literature on the role of chemokines as mediators of neovascularization.
More Related Videos
09:03Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
09:42Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
Published on: June 26, 2019
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
Mechanism of Angiogenesis
The Tumor Microenvironment
Paracrine Signaling
Overview of Cell-Matrix Interactions
Inflammation