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Updated: Jul 2, 2026

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Published on: August 11, 2023
Endolumenal fundoplication with EsophyX: the initial North American experience
Simon Bergman1, Dean J Mikami, Jeffrey W Hazey
1Department of Surgery, Center for Minimally Invasive Surgery, The Ohio State University, Columbus, Ohio 43210, USA.
The EsophyX device offers a new, safe option for GERD treatment by creating a valve in the stomach. Initial North American studies show it effectively reduces gastroesophageal reflux disease symptoms.
Area of Science:
- Gastroenterology
- Minimally Invasive Surgery
Background:
- Gastroesophageal reflux disease (GERD) affects millions globally.
- Conventional treatments include medication and traditional surgery.
- There is a need for novel, less invasive therapeutic options.
Purpose of the Study:
- To evaluate the safety and effectiveness of the EsophyX device.
- To assess the initial North American experience with endolumenal fundoplication.
- To characterize outcomes in patients undergoing GERD treatment with EsophyX.
Main Methods:
- Retrospective study of consecutive GERD patients.
- Endolumenal fundoplication using the EsophyX device.
- Assessment of proton pump inhibitor usage and validated quality of life/symptom severity questionnaires.
Main Results:
- The EsophyX procedure demonstrated safety in the initial North American cohort.
- Moderate effectiveness in alleviating GERD symptoms was observed.
- Improvements in GERD-related quality of life were noted.
Conclusions:
- Endolumenal fundoplication with EsophyX is a safe preliminary option for GERD.
- The device shows moderate effectiveness in managing GERD symptoms.
- Further comparative studies against standard therapies are warranted.
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