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Updated: Jul 2, 2026

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
Published on: April 2, 2020
Pontin and reptin, two related ATPases with multiple roles in cancer
Otmar Huber1, Ludovic Ménard, Valérie Haurie
1Department of Laboratory Medicine and Pathobiochemistry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Abstract:
Studies in model organisms or cultured human cells suggest potential implications in carcinogenesis for the AAA+ ATPases Pontin and Reptin. Both proteins are associated with several chromatin-remodeling complexes and have many functions including transcriptional regulation, DNA damage repair, and telomerase activity. They also interact with major oncogenic actors such as beta-catenin and c-myc and regulate their oncogenic function. We only now begin to get insight into the role of Pontin and Reptin in human cancers.
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