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Abnormal pain processing in chronic tension-type headache: a high-density EEG brain mapping study.

L Buchgreitz1, L L Egsgaard, R Jensen

  • 1Department of Neurology, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Nordre Ringvej, Glostrup, Copenhagen, Denmark. buchgreitz@dadlnet.dk

Brain : a Journal of Neurology
|September 2, 2008
PubMed
Summary

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Patients with chronic tension-type headache (CTTH) show abnormal brain responses to muscle pain, unlike healthy individuals. This suggests impaired pain inhibition may contribute to their condition.

Area of Science:

  • Neuroscience
  • Pain Research
  • Headache Disorders

Background:

  • Central sensitization from muscle nociception is key in chronic tension-type headache (CTTH).
  • Understanding supraspinal processing of muscle pain is crucial for CTTH pathophysiology.

Purpose of the Study:

  • Investigate spatiotemporal brain activity using high-density EEG in response to trapezius muscle pain.
  • Compare brain responses to induced muscle pain between CTTH patients and healthy controls.

Main Methods:

  • 19 CTTH patients and 19 healthy controls underwent high-density 128-channel EEG.
  • Somatosensory evoked potentials were recorded during baseline and induced tonic trapezius muscle pain (glutamate injection).
  • Intramuscular electrical stimuli (single and train of five pulses) were applied.

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Main Results:

  • Healthy controls showed a significant reduction in P200 dipole magnitude during and after induced muscle pain.
  • CTTH patients exhibited no significant changes in P200 dipole magnitude.
  • No consistent differences in dipole localization or peak latency were observed between groups.

Conclusions:

  • Impaired inhibition of nociceptive input in CTTH patients may explain the lack of pain-induced magnitude reduction.
  • This study provides evidence for abnormal supraspinal processing of muscle pain in CTTH.
  • Findings highlight potential differences in central pain processing mechanisms between CTTH patients and controls.