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Updated: Jul 2, 2026

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
Published on: February 3, 2023
The influence of gene conversion on linkage disequilibrium around a selective sweep
Danielle A Jones1, John Wakeley
1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. djones@fas.harvard.edu
Abstract:
In a 2007 article, McVean studied the effect of recombination on linkage disequilibrium (LD) between two neutral loci located near a third locus that has undergone a selective sweep. The results demonstrated that two loci on the same side of a selected locus might show substantial LD, whereas the expected LD for two loci on opposite sides of a selected locus is zero. In this article, we extend McVean's model to include gene conversion. We show that one of the conclusions is strongly affected by gene conversion: when gene conversion is present, there may be substantial LD between two loci on opposite sides of a selective sweep.
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