Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coronary Artery Revascularization in the Older Adult Population: A Scientific Statement From the American Heart Association.

Circulation·2025
Same author

Glycaemic control in labour with diabetes: GILD, a scoping study.

Health technology assessment (Winchester, England)·2025
Same author

Induction of labour care in the UK: A cross-sectional survey of maternity units.

PloS one·2024
Same author

Identification and treatment of individuals with attention-deficit/hyperactivity disorder and substance use disorder: An expert consensus statement.

World journal of psychiatry·2023
Same author

Adverse effects after first and second dose of covishield and covaxin: A longitudinal study.

Journal of family medicine and primary care·2023
Same author

Impact of Covid-19 lockdown on the emotional health of schoolchildren in an urban Indian setting.

The National medical journal of India·2023
Same journal

The pressurised leaky funnel: rethinking recruitment, selection and retention in the UK psychiatry workforce.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Cutting through stigma: psychiatry and neurosurgery working together.

The British journal of psychiatry : the journal of mental science·2026
Same journal

A fourth pillar for evidence-based medicine: implications for psychiatry - CORRIGENDUM.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Understanding negative perceptions of psychiatrists on social media: lessons from public discourse and professional self-reflection.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Attachment-informed psychopharmacology in psychiatric care.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Acceptability and accuracy of point-of-care monitoring of lithium levels.

The British journal of psychiatry : the journal of mental science·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2026

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

Middle-ear disease and schizophrenia: case-control study.

Peter Mason1, Michael Rimmer, Anna Richman

  • 1Cheshire & Wirral Partnership NHS Foundation Trust, The Stein Centre, St Catherine's Hospital, Birkenhead CH42 0LQ, UK. peter.mason@cwp.nhs.uk

The British Journal of Psychiatry : the Journal of Mental Science
|September 2, 2008
PubMed
Summary
This summary is machine-generated.

Middle-ear disease is linked to schizophrenia, with patients 3.68 times more likely to have had ear issues beforehand. This association, particularly on the left, may hold etiological significance for schizophrenia.

More Related Videos

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology
03:42

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology

Published on: May 18, 2022

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

Related Experiment Videos

Last Updated: Jul 2, 2026

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology
03:42

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology

Published on: May 18, 2022

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

Area of Science:

  • Neuroscience
  • Psychiatry
  • Otolaryngology

Background:

  • Historical psychiatric theories proposed ear disease could induce insanity via brain irritation.
  • Modern understanding of temporal lobe functions in schizophrenia and their proximity to the middle ear lends support to this hypothesis.

Purpose of the Study:

  • To determine the prevalence of middle-ear disease preceding the onset of schizophrenia.

Main Methods:

  • Eighty-four schizophrenia patients were matched with four controls each based on age, gender, and birth season.
  • Ear disease history was sourced from general practice records.
  • Case group participants provided symptom data and underwent audiometry.

Main Results:

  • A significant association was found between pre-schizophrenia middle-ear disease and schizophrenia (Odds Ratio = 3.68).
  • This association was more pronounced for left-sided middle-ear disease (OR = 4.15).
  • Auditory hallucinations correlated with middle-ear disease, but not with hearing loss.

Conclusions:

  • An association exists between middle-ear disease and schizophrenia.
  • This link may possess etiological significance in the development of schizophrenia.