Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mechanically-gated Ion Channels

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

Other Stress Responses in Bacteria

Other Stress Responses in Bacteria

Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...

Regulation of the Unfolded Protein Response

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...

Tension Response at Adherens Junctions

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...

Stress

Stress

When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...

Thermal Stress

Thermal Stress

If the temperature of an object is changed while it is prevented from expanding or contracting, the object is subjected to stress. The stress is compressive if the object expands in the absence of constraint and tensile if it contracts. This stress resulting from temperature change is known as thermal stress. It can be quite large and can cause damage. To avoid this stress, engineers may design components so they can expand and contract freely. For instance, on highways, gaps are deliberately...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Oral exposure to lead for Japanese children and pregnant women, estimated using duplicate food portions and house dust analyses.

Environmental health and preventive medicine·2019

Same author

Hijiki seaweed consumption elevates levels of inorganic arsenic intake in Japanese children and pregnant women.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment·2019

Same author

Lead Exposure Assessment among Pregnant Women, Newborns, and Children: Case Study from Karachi, Pakistan.

International journal of environmental research and public health·2017

Same author

External lead contamination of women's nails by surma in Pakistan: Is the biomarker reliable?

Environmental pollution (Barking, Essex : 1987)·2016

Same author

Heavy metal exposure, in combination with physical activity and aging, is related with oxidative stress in Japanese women from a rural agricultural community.

SpringerPlus·2016

Same author

Involvement of Transient Receptor Potential Vanilloid (TRPV) 4 in mouse sperm thermotaxis.

The Journal of reproduction and development·2016

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

Investigating Stress-relaxation and Failure Responses in the Trachea

Investigating Stress-relaxation and Failure Responses in the Trachea

Published on: October 18, 2022

[TRP channels and mechanical stress].

Atsuko Mizuno¹

¹Jichi Medical University.

Clinical Calcium

|September 2, 2008

Summary

Transient receptor potential (TRP) channels detect external stimuli, triggering calcium signals. The TRPV4 channel is crucial for mechanosensation in bone, highlighting TRP channels' diverse roles.

Area of Science:

Molecular biology
Cell physiology
Biophysics

Context:

Transient receptor potential (TRP) channels are critical cellular sensors.
These channels transduce various external stimuli into intracellular calcium signals.
Recent research highlights the role of TRP channels in bone biology.

Purpose:

To review the known functions of TRP channels.
To focus on the role of TRPV4 in bone mechanosensation.
To explore the broader implications of TRP channel activity.

Summary:

TRP channels are involved in sensing diverse environmental cues.
The vanilloid subfamily member, TRPV4, is identified as a key player in bone mechanosensation.
This review consolidates current understanding of TRP channel functions.

More Related Videos

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Related Experiment Videos

Last Updated: Jul 2, 2026

Investigating Stress-relaxation and Failure Responses in the Trachea

Investigating Stress-relaxation and Failure Responses in the Trachea

Published on: October 18, 2022

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Impact:

Provides a comprehensive overview of TRP channel functions.
Highlights the specific importance of TRPV4 in skeletal mechanotransduction.
Informs future research directions in bone physiology and TRP channel biology.