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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview

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Related Experiment Video

Updated: Jul 2, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

[Bisphosphonate and mechanical stress on bone].

Itsuro Endo1, Toshio Matsumoto

  • 1University of Tokushima Graduate School institute of Health Biosciences, Department of Medicine and Bioregulatory Sciences.

Clinical Calcium
|September 2, 2008
PubMed
Summary

Spaceflight and bed rest cause bone mineral loss, leading to osteoporosis. Bisphosphonates show promise as countermeasures for preventing and treating this bone loss.

Area of Science:

  • Bone biology and space medicine
  • Skeletal physiology and pathology

Context:

  • Bone mineral density loss is a known consequence of microgravity exposure (space flight) and prolonged physical inactivity (bed rest).
  • Understanding the precise mechanisms driving disuse osteoporosis remains a critical challenge in both space medicine and terrestrial healthcare.

Purpose:

  • To review the current understanding of bisphosphonates' effects on unloading-induced osteoporosis.
  • To explore the potential of bisphosphonates as a countermeasure for bone loss during space missions and bed rest.

Summary:

  • Bisphosphonates are investigated for their role in preventing and treating osteoporosis caused by reduced mechanical loading.
  • This review synthesizes existing research on bisphosphonates' efficacy and mechanisms in mitigating bone loss associated with space flight and bed rest.

More Related Videos

Mouse Lumbar Vertebra Uniaxial Compression Testing with Embedding of the Loading Surface
07:52

Mouse Lumbar Vertebra Uniaxial Compression Testing with Embedding of the Loading Surface

Published on: December 1, 2023

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

Related Experiment Videos

Last Updated: Jul 2, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

Mouse Lumbar Vertebra Uniaxial Compression Testing with Embedding of the Loading Surface
07:52

Mouse Lumbar Vertebra Uniaxial Compression Testing with Embedding of the Loading Surface

Published on: December 1, 2023

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

Impact:

  • Bisphosphonates may offer a viable therapeutic strategy to preserve bone health in astronauts and individuals experiencing prolonged immobility.
  • Further research into bisphosphonates could lead to improved treatments for osteoporosis in various clinical settings.