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Updated: Jul 2, 2026
A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Identification of a new cytotoxic biflavanone from Selaginella doederleinii
Na-Youn Lee1, Hye-Young Min, Jun Lee
1College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans University, Seoul, Korea.
Abstract:
A new biflavanone, 2,2'',3,3''-tetrahydrorobustaflavone 7,4',7''-trimethyl ether (1) was isolated from the whole plant of Selaginella doederleinii HIERON. (Selaginellaceae) together with the known biflavonoid, robustaflavone 7,4',7''-trimethyl ether (2) as the cytotoxic constituents against the three human cancer cell lines, HCT, NCI-H358, and K562. The structure of the new compound 1 was elucidated by spectral analysis including various 1D- and 2D-NMR experiments.
