Related Experiment Video

Updated: Jul 2, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

The relationship between vascular endothelial growth factor (VEGF) and microalbuminuria in patients with essential

Fatma Ayerden Ebinç1, Ebinç Haksun, Derici Boztepe Ulver

  • 1Faculty of Medicine, Department of Nephrology, Gazi University. fayerdenebin@yahoo.com

Internal Medicine (Tokyo, Japan)
|September 2, 2008
PubMed
Abstract

Insights

Serum vascular endothelial growth factor (VEGF) levels are elevated in patients with essential hypertension and microalbuminuria (MAU). This suggests VEGF may play a role in early vascular damage diagnosis in hypertensive individuals.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Microalbuminuria (MAU) in essential hypertension (EHs) indicates microvascular damage.
  • Endothelial dysfunction and increased vascular permeability contribute to MAU pathogenesis.
  • Vascular endothelial growth factor (VEGF) regulates angiogenesis and vascular permeability.

Purpose of the Study:

  • To investigate the association between serum VEGF levels and MAU in newly-diagnosed, uncomplicated essential hypertensive patients.
  • To explore VEGF's role in the early stages of vascular damage in hypertension.

Main Methods:

  • Study included 30 EHs with MAU, 46 EHs without MAU, and 46 healthy controls.
  • Exclusion criteria: diabetes, renal impairment, atherosclerotic diseases.
  • Serum VEGF levels were quantified using the ELISA method.

Main Results:

  • Serum VEGF levels were significantly higher in EHs with MAU compared to EHs without MAU (p=0.04) and controls (p=0.007).
  • No significant difference in VEGF levels was found between non-MAU EHs and controls.
  • VEGF levels positively correlated with systolic blood pressure, diastolic blood pressure, mean arterial pressure, creatinine clearance, and MAU (p<0.05).
  • Multiple regression analysis confirmed VEGF was independently related to MAU (p=0.02).

Conclusions:

  • Elevated serum VEGF levels are associated with the presence of MAU in essential hypertension.
  • High VEGF may serve as an early biomarker for vascular damage in hypertensive patients.
  • VEGF might contribute to increased glomerular permeability, leading to MAU in EHs.

More Related Videos

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts05:56

Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts

Published on: January 22, 2020

Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...