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Updated: Jul 2, 2026
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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
Plasmoblastic lymphoma associated with human immunodeficiency virus.
Emoke Horváth1, L Krenács, Eniko Bagdi
1Department of Pathology, University of Medicine and Pharmacy of Targu Mures, Romania. horvath_emoke@yahoo.com
Summary
Plasmoblastic lymphoma (PBL), an aggressive cancer linked to HIV/AIDS, can manifest in the oral cavity. Early diagnosis relies on integrating histopathology, immunohistochemistry, and clinical findings.
Area of Science:
- Oncology
- Immunology
- Oral Pathology
Background:
- Plasmoblastic lymphoma (PBL) is an aggressive subtype of diffuse large B-cell lymphoma.
- PBL frequently presents as extranodal disease in individuals with human immunodeficiency virus (HIV) infection.
- PBL can be an initial manifestation of acquired immunodeficiency syndrome (AIDS).
Observation:
- A case of oral cavity PBL involving the maxilla and gingiva is presented.
- Histopathological analysis revealed massive infiltration by large lymphoid cells.
- Immunohistochemical staining showed expression of CD79a, CD138, cytoplasmic lambda light chain, and LCA, with negativity for CD20, CD38, CD3, and CTK.
Findings:
- The patient was diagnosed with HIV positivity.
- PBLs often lack typical B-lineage markers, complicating differential diagnosis.
- Immunohistochemical markers like CD79a can be expressed in some PBL cells.
Implications:
- Accurate diagnosis of oral PBL requires a comprehensive approach.
- Correlating histopathological and immunohistochemical findings with clinical presentation and serology is crucial.
- This case highlights the importance of considering PBL in HIV-positive patients with oral lesions.
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