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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Related Experiment Video

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Quantifying Mixing using Magnetic Resonance Imaging
07:33

Quantifying Mixing using Magnetic Resonance Imaging

Published on: January 25, 2012

Quantifying magnetic nanoparticles in non-steady flow by MRI.

Yimin Shen1, Yu-Chung N Cheng, Gavin Lawes

  • 1Department of Radiology, Wayne State University, Detroit, MI 48201, USA.

Magma (New York, N.Y.)
|September 2, 2008
PubMed
Summary

The static dephasing theory accurately predicts magnetic nanoparticle behavior in phantoms and dynamic flows, enabling quantification of nanoparticle concentration or susceptibility for potential in vivo applications.

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Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
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Area of Science:

  • Biomedical Engineering
  • Magnetic Resonance Imaging
  • Nanotechnology

Background:

  • Magnetic nanoparticles (MNPs) are increasingly used in biomedical applications.
  • Accurate characterization of MNPs in various environments is crucial for their effective use.
  • Existing methods for MNP quantification have limitations in dynamic settings.

Purpose of the Study:

  • To compare measured R*2 values of magnetic nanoparticles with theoretical predictions.
  • To validate the static dephasing theory in both static (gel phantoms) and dynamic (water flows) conditions.
  • To assess the potential of this theory for quantifying MNP properties in vivo.

Main Methods:

  • Magnetic moment of MNP solutions measured using a magnetometer.
  • R*2 values determined in gel phantoms at 1.5 T and 4.7 T.
  • Dynamic flow experiments conducted with varying MNP concentrations, measuring R*2 over time.

Main Results:

  • Theoretical R*2 values agreed within 11% of MRI measurements in gel phantoms.
  • In dynamic flow experiments, 10 out of 12 cases showed agreement within 15% between calculated and theoretical R*2.
  • MRI phase values were reasonably predicted by the static dephasing theory; diffusion effects were minimal.

Conclusions:

  • The static dephasing theory provides a reliable method for quantifying MNP susceptibility or concentration.
  • This quantification is achievable in both static and dynamic flow environments at specific time points.
  • The validated approach holds promise for future in vivo studies involving magnetic nanoparticles.