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Etiological profile of stroke and its relation with prothrombotic states

Sonia Makhija1, Satinder Aneja, R P Tripathi

  • 1Department of Pediatrics, Lady Hardinge Medical College, Delhi, India. sachinmakhija25573@yahoo.com

Indian Journal of Pediatrics
|September 2, 2008
PubMed

Insights

Childhood stroke often links to prothrombotic states like antiphospholipid antibody syndrome. Further investigation with Magnetic Resonance Angiography and ELISA is recommended for unexplained pediatric stroke cases.

Area of Science:

  • Pediatric Neurology
  • Hematology
  • Vascular Medicine

Background:

  • Childhood stroke is a significant cause of long-term disability.
  • Identifying the etiology of pediatric stroke is crucial for effective management and prevention.
  • Prothrombotic states are increasingly recognized as a contributing factor in childhood stroke.

Purpose of the Study:

  • To investigate the etiological profile of acute stroke in children.
  • To determine the association between childhood stroke and prothrombotic states.

Main Methods:

  • A case-control study involving 66 children (36 cases, 30 controls) with acute stroke.
  • Stroke confirmation via CT and MRI; cardiac assessment by echocardiography.
  • Testing for hypercoagulable states including antiphospholipid antibodies, antithrombin III, protein C, and protein S.

Main Results:

  • Common presenting symptoms included motor deficit (72%) and seizures (66%).
  • Identified causes: antiphospholipid antibody syndrome (25%), Moya Moya disease (16.6%), cardiac disease (11.1%), and various deficiencies (e.g., ATIII deficiency 5.5%).
  • Etiology remained unknown in 25% of ischemic stroke cases; hemorrhagic stroke was linked to DIC or liver disease.

Conclusions:

  • Antiphospholipid antibody syndrome is a significant cause of childhood stroke.
  • Magnetic Resonance Angiography and ELISA for antiphospholipid antibodies are recommended for children with unexplained stroke.
Abstract

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