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Related Experiment Video

Updated: Jul 2, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

Migraine genetics.

Pasquale Montagna¹

¹Department of Neurological Sciences, University of Bologna Medical School, Via U. Foscolo 7, 40123 Bologna, Italy. pasquale.montagna@unibo.it

Expert Review of Neurotherapeutics

|September 2, 2008

Summary

This summary is machine-generated.

Familial hemiplegic migraine (FHM) has a distinct genetic basis from typical migraines (migraine with aura/migraine without aura). Further research into typical migraine genetics, potentially involving epigenetic mechanisms, is warranted.

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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Area of Science:

Neuroscience
Genetics
Medical Research

Background:

Migraine with aura (MA) and migraine without aura (MO) are common primary headaches with significant familial links.
Familial hemiplegic migraine (FHM), a subtype of MA, exhibits autosomal dominant inheritance due to specific gene mutations.
However, these FHM mutations are rare in typical migraines, suggesting different genetic underpinnings.

Purpose of the Study:

To differentiate the genetic basis of familial hemiplegic migraine (FHM) from typical migraines (MA/MO).
To explore potential genetic factors contributing to typical migraine susceptibility.
To propose the involvement of epigenetic mechanisms in the genetics of typical migraines.

Main Methods:

Review of existing literature on migraine genetics.
Analysis of genetic transmission patterns in FHM versus typical migraines.
Genome-wide scans and linkage analyses in families with MA/MO.

Main Results:

FHM mutations account for a small fraction of FHM cases and are not typically found in MA or MO.
This indicates FHM may be a distinct syndromic migraine, not merely a subtype of MA.
Linkage and genome-wide scans have identified chromosomal liability loci for MA/MO.

Conclusions:

The genetic predisposition for typical migraines likely differs from FHM.
Future research may uncover specific genes responsible for typical migraines.
Epigenetic mechanisms, particularly during neural development, are proposed as key factors in typical migraine genetics.