Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patellar Reconstruction During Total Knee Arthroplasty for Previous Patellectomy.

Arthroplasty today·2026
Same author

Efficacy and safety of N-acetylcysteine in patients with mild cognitive impairment undergoing exercise-based cardiac rehabilitation program: a randomized controlled trial.

Alzheimer's research & therapy·2026
Same author

A Brief Intervention for the Treatment of Anxiety in Pregnancy: A Pilot Randomized Controlled Trial (The TAP Study).

Psychotherapy and psychosomatics·2026
Same author

ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: A human and experimental study.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Femoral Bowing in Total Knee Arthroplasty: Angular Deviation as a Primary Mediator of Poor Five-Year Function and Evidence-Based Thresholds for Intervention.

The Journal of arthroplasty·2026
Same author

Using a robotic-arm assisted system in revision total hip arthroplasty: surgical technique and a case series.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2026
Same journal

Beyond the Wait-and-See: Data-Driven Decision Points for Guiding Selective Serotonin Reuptake Inhibitor Treatment and Cognitive Behavioral Therapy in Pediatric Anxiety Disorders.

Journal of child and adolescent psychopharmacology·2026
Same journal

Efficacy and Safety of Cannabinoid-Based Products in Children and Adolescents with Autism Spectrum Disorder, Fragile X Syndrome and Rett Syndrome: A Systematic Review.

Journal of child and adolescent psychopharmacology·2026
Same journal

Low Emotional Awareness and Altered Frontostriatal Functional Connectivity During Reward Processing Prospectively Predict Depressive Symptoms in At-Risk Youth.

Journal of child and adolescent psychopharmacology·2026
Same journal

Testing a Developmental Cascade Model from Prenatal Maternal Emotion Dysregulation to Toddler Behavior Dysregulation Through Postnatal Parenting Stress and Infant Physiology.

Journal of child and adolescent psychopharmacology·2026
Same journal

Neighborhood Disadvantage as a Moderator of Children's Response to a Dyadic Positive Affect Intervention for Children of Mothers with Depressive Symptoms.

Journal of child and adolescent psychopharmacology·2026
Same journal

<i>Letter:</i> Psychosis Following Hormonal Therapy in NAA15-Related Neurodevelopmental Disorder.

Journal of child and adolescent psychopharmacology·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Maintenance study for adolescent depression.

Amy Cheung1, Vivek Kusumakar, Stan Kutcher

  • 1Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. dramy.cheung@gmail.com

Journal of Child and Adolescent Psychopharmacology
|September 2, 2008
PubMed
Summary
This summary is machine-generated.

This study suggests that maintenance treatment with sertraline may benefit adolescents with major depression after initial response. Further research is needed to confirm these findings for adolescent depression treatment.

More Related Videos

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

Related Experiment Videos

Last Updated: Jul 2, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Antidepressant efficacy in acute adolescent depression is established.
  • Limited data exist on the long-term benefits of antidepressants in this population.
  • Maintenance treatment is crucial for preventing relapse in major depressive disorder.

Purpose of the Study:

  • To evaluate the efficacy of continued sertraline treatment for major depression in adolescents post-acute response.
  • To assess the benefit of maintenance therapy using a randomized placebo-controlled discontinuation design.

Main Methods:

  • Adolescents (13-19 years) with major depression, who responded to open-label sertraline, were randomized to placebo or continued sertraline.
  • Treatment duration for maintenance was 52 weeks.
  • Relapse rates were compared between the sertraline and placebo groups.

Main Results:

  • A higher proportion of subjects on sertraline (38%) remained well compared to placebo (0%).
  • Survival analysis did not reveal statistically significant differences between groups (p=0.17).
  • The study included a small sample size (n=22).

Conclusions:

  • This is the first study on maintenance treatment outcomes for adolescent major depression.
  • Findings suggest a potential benefit of sertraline maintenance over placebo.
  • A larger, adequately powered trial is necessary to confirm these preliminary results.