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Updated: Jul 2, 2026
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Published on: October 16, 2013
Hypersensitivity to local anaesthetics--update and proposal of evaluation algorithm.
Jacob Pontoppidan Thyssen1, Torkil Menné, Jesper Elberling
1Department of Dermatology, National Allergy Research Centre, Copenhagen, Dennmark. jacpth01@geh.regionh.dk
Contact Dermatitis
|September 2, 2008
Summary
Adverse reactions to local anaesthetics (LA) can be immediate or delayed. Allergy skin testing is crucial for diagnosis, and a new algorithm can help differentiate these reaction types safely and quickly.
Area of Science:
- Allergy and Immunology
- Pharmacology
Background:
- Local anaesthetics (LA) are frequently used medications with rare adverse reactions.
- Differentiating between immediate and delayed hypersensitivity reactions to LA can be challenging clinically.
Purpose of the Study:
- To provide a comprehensive review of allergic reactions to local anaesthetics.
- To propose an algorithm for evaluating patients with suspected immune reactions to LA.
Main Methods:
- Literature search conducted across PubMed-Medline, EMBASE, Biosis, and Science Citation Index.
- Review of published test protocols for allergy skin testing related to LA hypersensitivity.
Main Results:
- Allergic reactions to LA can manifest as immediate or delayed hypersensitivity.
- Allergy skin testing is a recommended diagnostic tool for suspected LA hypersensitivity.
Conclusions:
- The proposed algorithm facilitates safe and rapid distinction between immediate and delayed allergic immune reactions to LA.
- Standardized evaluation is essential for accurate diagnosis and management of LA hypersensitivity.
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