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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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Related Experiment Video

Updated: Jul 2, 2026

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
09:02

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

Crack cocaine and infectious tuberculosis.

Alistair Story1, Graham Bothamley, Andrew Hayward

  • 1Tuberculosis Section, Respiratory Diseases Department, Health Protection Agency, London, UK. alistair.story@hpa.org.uk

Emerging Infectious Diseases
|September 2, 2008
PubMed
Summary

Crack cocaine use is linked to a higher likelihood of smear-positive tuberculosis (TB). This finding suggests respiratory damage from crack cocaine may increase infectiousness in tuberculosis patients.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Substance Abuse Research

Background:

  • Tuberculosis (TB) remains a global health challenge, particularly in urban settings.
  • Understanding risk factors for infectious TB is crucial for effective control strategies.
  • The impact of specific substance use, like crack cocaine, on TB transmission requires further investigation.

Purpose of the Study:

  • To investigate the association between crack cocaine use and smear-positive pulmonary tuberculosis.
  • To determine if crack cocaine use is an independent risk factor for infectious TB.

Main Methods:

  • A case-control study was conducted in London.
  • Cases included patients with pulmonary tuberculosis.
  • Controls were individuals without TB, including non-drug users.

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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

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Last Updated: Jul 2, 2026

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
09:02

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

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Main Results:

  • A significantly higher proportion of crack cocaine users (86%) had smear-positive pulmonary TB compared to non-drug users (36%).
  • Out of 22 crack cocaine users with pulmonary TB, 19 were smear positive.
  • Out of 833 non-drug users, 302 had smear-positive pulmonary TB.

Conclusions:

  • Crack cocaine use is independently associated with smear-positive tuberculosis.
  • Respiratory damage induced by crack cocaine may enhance the infectivity of individuals with TB.
  • This highlights a potential public health concern linking substance abuse and TB transmission.