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Updated: Jul 2, 2026

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
Published on: February 16, 2020
Diagnostic challenges of central nervous system tuberculosis
Laura J Christie1, Ann M Loeffler, Somayeh Honarmand
1Viral and Rickettsial Disease Laboratory, California Department of Public Health, Richmond, California 94804, USA. laura.christie@cdph.ca.gov
Abstract:
Central nervous system tuberculosis (TB) was identified in 20 cases of unexplained encephalitis referred to the California Encephalitis Project. Atypical features (encephalitic symptoms, rapid onset, age) and diagnostic challenges (insensitive cerebrospinal fluid [CSF] TB PCR result, elevated CSF glucose levels in patients with diabetes, negative result for tuberculin skin test) complicated diagnosis.
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