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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

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Published on: June 13, 2021

Perinatal depression.

Emily C Dossett1

  • 1Department of Psychiatry and Biobehavioral Sciences, LAC-USC Medical Center, Los Angeles, CA 90033, USA. edosset@edossettmd.com

Obstetrics and Gynecology Clinics of North America
|September 2, 2008
PubMed
Summary
This summary is machine-generated.

Perinatal depression affects many families, but early identification and treatment are crucial for maternal and infant well-being. Antidepressant medications can be safe and effective for severe cases in pregnant or breastfeeding individuals.

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Last Updated: Jul 2, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

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Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Mental Health
  • Psychiatry

Background:

  • Perinatal depression is a common complication of childbirth.
  • Untreated perinatal depression poses risks to both mother and child.
  • Effective management strategies are vital for positive birth outcomes.

Purpose of the Study:

  • To highlight the prevalence and significance of perinatal depression.
  • To emphasize the importance of timely diagnosis and intervention.
  • To discuss the role of antidepressant medication in managing severe perinatal depression.

Main Methods:

  • Literature review on perinatal depression prevalence and impact.
  • Analysis of treatment guidelines for perinatal depression.
  • Risk-benefit assessment of antidepressant use during pregnancy and lactation.

Main Results:

  • Perinatal depression is highly prevalent, affecting numerous families.
  • Failure to treat can lead to severe maternal and infant morbidity and mortality.
  • Antidepressant medications are generally safe for severely depressed pregnant or lactating patients.

Conclusions:

  • Early identification and treatment of perinatal depression are essential.
  • Informed consent and risk-benefit analysis guide medication choices.
  • Antidepressants are indicated for severe perinatal depression when benefits outweigh risks.