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Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Related Experiment Video

Updated: Jul 2, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
08:01

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Translational integrity and continuity: personalized biomedical data integration.

Xiaoming Wang1, Lili Liu, James Fackenthal

  • 1Biomedical Informatics Core, Computation Institute, University of Chicago, 950 E 61st Street, Room 334, Chicago, IL 60637, USA. xiaoming@uchicago.edu

Journal of Biomedical Informatics
|September 2, 2008
PubMed
Summary
This summary is machine-generated.

We developed TraM, a data management system to integrate fragmented translational research data. TraM uses an ontology-based model to improve data quality and cross-domain querying for human-centered records.

Related Experiment Videos

Last Updated: Jul 2, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
08:01

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Area of Science:

  • Biomedical Informatics
  • Translational Science
  • Data Management

Background:

  • Translational research generates diverse data stored in fragmented, inconsistent databases.
  • Data silos impede efficient tracking and analysis of human-centered records.
  • Inconsistent terminologies across research domains hinder data integration.

Purpose of the Study:

  • To develop a flexible data repository and management system for translational research.
  • To address challenges of data fragmentation and inconsistency in translational research.
  • To enhance data quality and enable cross-domain querying.

Main Methods:

  • Developed the TraM (Translational research data management) system.
  • Utilized a domain ontology-integrated entity relationship model.
  • Implemented a semi-automated mechanism for data standardization and restructuring.

Main Results:

  • TraM supports data integration for a broad range of translational research.
  • The system offers dynamic recruitment of evolving domain concepts.
  • Web-based interfaces facilitate data curation and user-friendly cross-domain queries.

Conclusions:

  • TraM provides a robust solution for managing heterogeneous translational research data.
  • The system improves data quality and facilitates analysis of human-centered records.
  • Current limitations include the lack of real-time data application support.