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Related Experiment Video

Updated: Jul 2, 2026

The Impact of Motor Task Conditions on Goal-Directed Arm Reaching Kinematics and Trunk Compensation in Chronic Stroke Survivors
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Hand function in multiple sclerosis: force coordination in manipulation tasks.

Vennila Krishnan1, Slobodan Jaric

  • 1Department of Health, Nutrition, and Exercise Sciences, Human Performance Lab, University of Delaware, 541 S. College Avenue, Newark, DE 19716, USA.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|September 2, 2008
PubMed
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This study shows a new method can detect hand dysfunction in multiple sclerosis (MS) patients. The technique measures grip and load forces during manipulation tasks, revealing subtle impairments.

Area of Science:

  • Neurology
  • Biomechanics
  • Rehabilitation Science

Background:

  • Multiple sclerosis (MS) often causes functional impairment, affecting hand dexterity.
  • Assessing subtle hand dysfunction in early-stage MS is crucial for timely intervention.

Purpose of the Study:

  • To evaluate a novel methodology for quantifying hand function in multiple sclerosis (MS).
  • To explore the pattern of grip (G) and load (L) forces during manipulation tasks to detect functional impairment.

Main Methods:

  • Twelve individuals with mild MS (EDSS 2.5-5.5) and 12 healthy controls performed static and dynamic manipulation tasks.
  • An instrumented device recorded grip force and load force, analyzing indices of task performance and force coordination (G/L ratio).

Main Results:

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Last Updated: Jul 2, 2026

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Published on: May 2, 2021

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  • MS patients demonstrated significantly lower task performance indices compared to controls.
  • Impaired force coordination, including G/L ratio and force modulation, was consistently observed in MS patients across all tasks.

Conclusions:

  • The force-pattern analysis methodology is sensitive in detecting hand dysfunction in individuals with mild MS.
  • This method shows potential as a standardized clinical test for assessing hand function in MS and other neurological conditions.