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Updated: Jul 2, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Regulation of p53R2 and its role as potential target for cancer therapy

Xin Wang1, Anna Zhenchuk, Klas G Wiman

  • 1Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institute, Karolinska Hospital, SE-171 76 Stockholm, Sweden.

Cancer Letters
|September 2, 2008
PubMed

Insights

p53R2, a protein crucial for DNA repair and mtDNA synthesis, shows promise as a cancer diagnostic marker. Its levels correlate with drug sensitivity and tumor invasiveness, suggesting its potential as an anticancer drug target.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Oncology

Background:

  • p53R2 is a recently identified subunit of human ribonucleotide reductase.
  • This protein is implicated in critical cellular processes including DNA repair, mitochondrial DNA (mtDNA) synthesis, and cellular defense against oxidative stress.

Purpose of the Study:

  • To investigate the role of p53R2 in cancer.
  • To evaluate p53R2 as a potential diagnostic marker and therapeutic target in oncology.

Main Methods:

  • Correlation analysis of p53R2 protein levels with drug sensitivity.
  • Assessment of p53R2 levels in relation to tumor invasiveness.

Main Results:

  • A positive correlation was observed between p53R2 protein levels and patient sensitivity to anticancer drugs.
  • Elevated p53R2 levels were associated with increased tumor invasiveness.

Conclusions:

  • p53R2 plays significant roles in DNA repair and cellular protection, impacting cancer progression.
  • The correlation of p53R2 levels with drug sensitivity and invasiveness highlights its potential as a predictive biomarker and a therapeutic target for novel anticancer strategies.

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