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Updated: Jul 2, 2026

Scratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound Healing
Published on: September 26, 2019
Regulation of K(+) channels may enhance wound healing in the skin
Dawon Kang1, Tae Hyun Choi, Kihwan Han
1Department of Physiology, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Abstract:
In the process of promoting wound healing, epidermal growth factor (EGF) activates protein kinase C, protein tyrosine kinase and ERK MAPK (mitogen-activated protein kinase). The activation of these mediators in signal pathways can regulate the operation of K(+) channels. In addition, the K(+) channel is involved with cell migration and proliferation, both of which are requisite for wound healing. Recent studies, although not conducted on skin wounds, have found that the K(+) channel is associated with wound healing and that wound healing can be promoted by regulating the K(+) channels. Therefore, the authors hypothesize that healing of skin wounds could be promoted by regulating K(+) channel distribution in skin keratinocytes or fibroblasts. We plan to conduct a study of the promotion of skin wound healing using K(+) channel regulators.
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