Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ureteral access sheath-related injuries vs. post-operative infections. Is sheath insertion always needed? A prospective randomized study to understand the lights and shadows of this practice.

Actas urologicas espanolas·2021

Same author

Ureteral access sheath-related injuries vs. post-operative infections. Is sheath insertion always needed? A prospective randomized study to understand the lights and shadows of this practice.

Actas urologicas espanolas·2021

Same author

[The use of RCGO triggers in the obstetric - gynecological procedures: the impact on the reduction of adeverse events. The experience of the Lombardia Region].

Igiene e sanita pubblica·2020

Same author

Evidence-Based Medicine and Clinical Practice: the first Italian attempt to define the appropriateness of rehabilitation admission criteria through the application of the Delphi method.

Annali di igiene : medicina preventiva e di comunita·2019

Same author

Active surveillance for antenatally detected ureteroceles: Predictors of success.

Journal of pediatric urology·2018

Same author

Scoring systems for Oral Lichen Planus used by differently experienced raters.

Medicina oral, patologia oral y cirugia bucal·2017

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

Published on: July 4, 2007

Optimal control strategy of malaria vector using genetically modified mosquitoes.

M Rafikov¹, L Bevilacqua, A P P Wyse

¹UFABC and UNIJUI, Rua Santa Adélia, 166, Bairo Bangu, 09210-170 Santo André, SP, Brazil. marat.rafikov@ufabc.edu.br

Journal of Theoretical Biology

|September 2, 2008

Summary

Genetically modified mosquitoes engineered to resist diseases offer a novel disease control strategy. Mathematical modeling demonstrates optimal introduction methods for these transgenic mosquitoes to effectively combat malaria.

More Related Videos

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes

Published on: May 1, 2021

Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes

Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes

Published on: July 4, 2007

Related Experiment Videos

Last Updated: Jul 2, 2026

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

Published on: July 4, 2007

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes

Published on: May 1, 2021

Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes

Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes

Published on: July 4, 2007

Area of Science:

Genetics
Epidemiology
Mathematical Biology

Background:

Transgenic mosquitoes offer a novel approach to disease control by inhibiting pathogen evolution.
The success of this strategy depends on the survival and competitiveness of genetically modified mosquitoes against wild populations.
Hereditary traits in transgenic mosquitoes can lead to a long-term reduction in disease prevalence.

Purpose of the Study:

To develop a mathematical model for analyzing the population dynamics of transgenic mosquitoes.
To formulate and solve an optimal control problem for the introduction of genetically modified mosquitoes.
To assess the effectiveness of transgenic mosquito strategies for malaria vector control.

Main Methods:

A continuous mathematical model was developed to simulate mosquito population dynamics.
The model incorporates factors such as generation overlapping and environmental variability.
Optimal control theory was applied to determine the best introduction strategy for transgenic mosquitoes.

Main Results:

Numerical simulations demonstrated the effectiveness of the proposed optimal control strategy.
The model provides insights into how to best release genetically modified mosquitoes for disease control.
The study highlights the potential of transgenic mosquitoes in malaria vector management.

Conclusions:

Transgenic mosquitoes represent a promising tool for disease control, particularly for malaria.
Mathematical modeling and optimal control are crucial for planning the effective deployment of genetically modified organisms.
The hereditary nature of disease resistance in transgenic mosquitoes suggests a sustainable approach to vector control.